| Bioactivity | Fosdevirine (GSK2248761) is is a potent, selective, non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1) replication with low nanomolar activity in vitro. Fosdevirine shows good activity against a broad range of HIV-1 strains, including efavirenz (HY-10572)-resistant clinical isolates[1]. |
| Invitro | Fosdevirine 对 K103N 和 Y181C 单点突变表现出强大的体外抗病毒功效，对大多数双突变体也同样有效[1]。 |
| Name | Fosdevirine |
| CAS | 1018450-26-4 |
| Formula | C20H17ClN3O3P |
| Molar Mass | 413.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Castellino S, et al. Central nervous system disposition and metabolism of Fosdevirine (GSK2248761), a non-nucleoside reverse transcriptase inhibitor: an LC-MS and Matrix-assisted laser desorption/ionization imaging MS investigation into central nervous system toxicity. Chem Res Toxicol. 2013 Feb 18;26(2):241-51. |
Fosdevirine
CAS: 1018450-26-4 F: C20H17ClN3O3P W: 413.79
Fosdevirine (GSK2248761) is is a potent, selective, non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immu
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