| Bioactivity | Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 prodrug that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis[1][3]. |
| Invitro | Fosbretabulin disodium inhibits growth of leukemia P-388, pancreas BXPC-3,neuroblast SK-N-SH, thyroid SW1736, lung-NSC NCI-H460, prostate DU-145, an pharynx FADU, with EC50s of 0.0029, 0.23, 0.00025, 0.00061, 0.00035, 0.00072, and 0.00045 μg/mL, respectively[2]. |
| Name | Fosbretabulin disodium |
| CAS | 168555-66-6 |
| Formula | C18H19Na2O8P |
| Molar Mass | 440.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Fosbretabulin disodium
CAS: 168555-66-6 F: C18H19Na2O8P W: 440.29
Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 prodru
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