| Bioactivity | Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1]. | ||||||||||||
| Target | Ki: 57 pM (PAF binding) | ||||||||||||
| Name | Foropafant | ||||||||||||
| CAS | 136468-36-5 | ||||||||||||
| Formula | C28H40N4S | ||||||||||||
| Molar Mass | 464.72 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Herbert JM, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51. |
Foropafant
CAS: 136468-36-5 F: C28H40N4S W: 464.72
Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (P
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