| Bioactivity | Folinic acid (Leucovorin) calcium hydrate is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity[1]. |
| Invitro | Methotrexate (MTX) alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid calcium hydrate at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid calcium hydrate (12 to 54% for MNBN and 20 to 61% for Abs) [1]. |
| Name | Folinic acid calcium hydrate |
| CAS | 1097832-14-8 |
| Formula | C20H25CaN7O8 |
| Molar Mass | 531.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Folinic acid calcium hydrate
CAS: 1097832-14-8 F: C20H25CaN7O8 W: 531.53
Folinic acid (Leucovorin) calcium hydrate is a biological folic acid and is generally administered along with Methotrexa
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.