| Bioactivity | Folic acid-13C6 is a deuterated labeled Folic acid[1]. Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency[2][3][4][5]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。Folic acid 在预防染色体断裂和 DNA 低甲基化方面起着关键作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Folic acid-13C6 相关抗体: |
| In Vivo | Folic acid 在预防染色体断裂和 DNA 低甲基化方面起着关键作用[2]。Folic acid (10、50、100 mg/kg；口服) 在该行为小鼠模型中显示出抗抑郁样作用[3]。 Folic acid (1、10 nmol/位点) 对适应新环境的小鼠没有精神刺激作用[3]。 Folic acid (1、5 mg/kg；口服) 可防止大鼠后代肝脏基因表达的表观遗传修饰[4]。大鼠口服叶酸水溶液时，AUC 为 1.4 μg h/mL，口服生物利用度为 35%[6]。 .f12{ font-size: 12px; } .fwb{ font-weight: bold; } .lh22{ line-height: 22px;; } .lh23 { line-height: 23px; } .pl13{ padding-left: 13px;; } .part { margin-top: 18px; } .mold-first-tit { width: 100%; height: 44px; line-height: 44px; background: #F9F7FB; border-bottom: 1px solid #EBE4F6; padding-left: 16px; box-sizing: border-box; margin-bottom: 17px; } .mold-second-tit:before { content:; width: 6px; height: 6px; display: inline-block; border-radius: 50%; background: rgba(255,102,0,0.4); margin-right: 12px; position: relative; top: -3px; } .lft-border { border-left: 1px dotted #EBE4F6; padding-right: 12px; margin-left: 3px; box-sizing: border-box; padding-bottom: 12px; } .dec { margin: 10px 15px 0; padding-bottom: 10px; border-bottom: 1px dashed #EBE4F6; } .btm-border { border-left: 1px dashed #EBE4F6; } .text-bg { margin-top: 10px; background: #FFFBF1; padding: 14px; border-bottom: 0; position: relative; } .text-note-bg { margin-top: 10px; background: #FFFDF7; padding: 12px; border-bottom: 0; position: relative; } .text-note { width: 51px; height: 20px; line-height: 20px; background: #FFE2AA; text-align: center; border-radius: 0 0 8px 0; position: absolute; top: 0; left: 0; } .text-note-dec { margin-top: 15px;; } 诱导急性肾损伤模型[7] 致病原理 Folic acid 需要更高水平的 NADPH 将叶酸还原为 THF，从而降低抗氧化防御能力。Folic acid 代谢引起的氧化还原失衡是肾损害的主要机制之一。 具体造模方法 Rat: Wistar • maleAdministration: 300mg/ml • i.p. • single dose Note (1) 给初始体重 230-250 g 的雄性 Wistar 大鼠腹腔注射叶酸 300 mg/kg (溶解于 300 mM NaHCO3)。(2) 在给药后第 2、4、7、14、28 天取血浆分析。 造模成功指标 代谢变化: 通过检测血尿素氮 (BUN) 和血浆肌酐评估肾损伤程度。个体表型变化: 检测肾重/大鼠总重比。 相关产品 Acetylcysteine (HY-B0215) MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 161406-20-8 |
| Formula | C1313C6H19N7O6 |
| Molar Mass | 447.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Butterworth CE Jr, et al. Folic acid safety and toxicity: a brief review. Am J Clin Nutr. 1989 Aug;50(2):353-8. [3]. Peñalva R, et al. Zein nanoparticles for oral folic acid delivery[J]. Journal of Drug Delivery Science and Technology, 2015, 30: 450-457. [4]. Brocardo PS, et al. Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology. 2008 Feb;54(2):464-73. [5]. Aparicio-Trejo OE, et al. Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med. 2020 Jul;154:18-32. [6]. Lillycrop KA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun;135(6):1382-6. [7]. Pietrzik K, et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48. |
Folic acid-13C6
CAS: 161406-20-8 F: C1313C6H19N7O6 W: 447.35
Folic acid-13C6 is a deuterated labeled Folic acid. Folic acid (Vitamin B9) is a orally active essential nutrient from t
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