| Bioactivity | Folate-FTIC (EC-17) is a folic acid derivative that binds to fluorescein isothiocyanate (FITC) to give it fluorescent labeling properties. Folate-ftic is used to induce the formation of pseudo-immunological synapses between anti-FITC CAR T cells and target cells expressing Folate receptors (FRα or FRβ). Folate-FTIC can be used to develop controlled CAR-T cell therapies for research in non-small cell lung cancer (NSCLC)[1]. |
| CAS | 583037-91-6 |
| Formula | C42H36N10O10S |
| Molar Mass | 872.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chu W, et al. Bi-specific ligand-controlled chimeric antigen receptor T-cell therapy for non-small cell lung cancer[J]. BioScience trends, 2018, 12(3): 298-308. |
Folate-FTIC
CAS: 583037-91-6 F: C42H36N10O10S W: 872.86
Folate-FTIC (EC-17) is a folic acid derivative that binds to fluorescein isothiocyanate (FITC) to give it fluorescent la
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