| Bioactivity | Fobrepodacin (SPR720) disodium is an orally active and potent phosphate prodrug of SPR719 (VXc-486; HY-12930). Fobrepodacin disodium has potent bactericidal activities in vivo[1]. |
| In Vivo | Fobrepodacin disodium (oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice[1]. Fobrepodacin disodium (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs[1]. Animal Model: |
| Name | Fobrepodacin disodium |
| CAS | 1384984-20-6 |
| Formula | C21H24FN6Na2O6P |
| Molar Mass | 552.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Locher CP, et al. A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65. |
Fobrepodacin disodium
CAS: 1384984-20-6 F: C21H24FN6Na2O6P W: 552.40
Fobrepodacin (SPR720) disodium is an orally active and potent phosphate prodrug of SPR719 (VXc-486; HY-12930). Fobrepoda
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