Fmoc-Val-Cit-PAB-PNP_product_DataBase

Bioactivity	Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Val-Cit-PAB-PNP has superior plasma stability comparable to that of non-cleavable linkers[1][2][3].
Invitro	Fmoc-Val-Cit-PAB-PNP contains peptide sequence degradable by a lysosome enzyme[1].Cathepsin B in the lysosome cleaves the peptide bond between Cit-PAB of dipeptide linkers containing Valine (Val)-citrulline (Cit) and p-aminobenzylalcohol (PAB). When PAB and a drug are binded covalently with carbamate bonds, the drug can be released by hydrolysis after cleavage of the peptide bond between Cit-PAB. Antibody-drug conjugates (ADCs) has been developed using this mechanism[2].
Name	Fmoc-Val-Cit-PAB-PNP
CAS	863971-53-3
Shortening	Fmoc-V-Cit-PAB-PNP
Formula	C40H42N6O10
Molar Mass	766.80
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

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