| Bioactivity | Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. | ||||||||||||
| Invitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. | ||||||||||||
| Name | Fmoc-Lys(Pal-Glu-OtBu)-OH | ||||||||||||
| CAS | 1491158-62-3 | ||||||||||||
| Formula | C46H69N3O8 | ||||||||||||
| Molar Mass | 792.06 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Fmoc-Lys(Pal-Glu-OtBu)-OH
CAS: 1491158-62-3 F: C46H69N3O8 W: 792.06
Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc
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