| Bioactivity | Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels. | ||||||||||||
| Invitro | Fluralaner potently inhibits flea reproduction capacity in vitro. Oviposition ceases completely at concentrations as low as 25.0 ng/mL. While no ovicidal effect is observed, fluralaner exerts a larvicidal effect at exceptionally low concentrations (6.25 ng/mL)[1]. | ||||||||||||
| In Vivo | In the simulated flea-infested home environment, flea-control efficacy on fluralaner-treated dogs is >99% at every time point measured for 12 weeks. No adverse events are observed in fluralaner-treated dogs. Fluralaner completely controls egg laying, larval development and flea reproduction even at sub-insecticidal concentrations. Oral treatment of dogs with fluralaner is highly effective for eliminating fleas in a simulated flea-infested home environment[1][2]. | ||||||||||||
| Name | Fluralaner | ||||||||||||
| CAS | 864731-61-3 | ||||||||||||
| Formula | C22H17Cl2F6N3O3 | ||||||||||||
| Molar Mass | 556.29 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Williams H, et al. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in asimulated home environment. Parasit Vectors. 2014 Jun 19;7:275. [2]. Walther FM, et al. Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(-/-) Collies after oral administration. Parasit Vectors. 2014 Mar 6;7:86. |
Fluralaner
CAS: 864731-61-3 F: C22H17Cl2F6N3O3 W: 556.29
Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gate
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