Fluparoxan

CAS: 105182-45-4 F: C10H10FNO2 W: 195.19

Fluparoxan is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan is an anti-depress

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Bioactivity	Fluparoxan is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan is an anti-depressant agent[1][2].
Invitro	在大鼠离体、场刺激输精管和豚鼠离体、场刺激回肠制剂中，Fluparoxan 是 α2-肾上腺素受体激动剂 UK-14304 (HY-B0659) 抑制反应的可逆竞争性拮抗剂，pKB 值分别为 7.87 和 7.89[1]。在大鼠离体尾尾肌中，Fluparoxan 是一种较弱的竞争性拮抗剂，可对抗 α1-肾上腺素受体激动剂 phenylephrine (HY-B0769) 的收缩反应，pKB 为 4.45，α2: α1-肾上腺素受体选择性比大于 2500[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Fluparoxan 相关抗体:
In Vivo	在清醒小鼠中，Fluparoxan (0.2-3.0 mg/kg) 通过口服途径有效，并且在预防 clonidine (HY-12721) 引起的体温过低和抗伤害方面与 idazoxan (HY-14561) 具有相似的效力[1]。Fluparoxan (0.67-6 mg/kg，口服)可预防 UK-14304 (HY-B0659) 引起的狗镇静和心动过缓[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	105182-45-4
Formula	C10H10FNO2
Molar Mass	195.19
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Halliday CA, et al. The pharmacology of fluparoxan: a selective alpha 2-adrenoceptor antagonist. Br J Pharmacol. 1991 Apr;102(4):887-95. [2]. Altria K D .High and low injection volumes in CE for improved quantitative determination of drug related impurities[J].Chromatographia, 1993, 35(9):493-496.

(S,R,S)-AHPC-CO-C9-NH2

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