Fluorofolin_product_DataBase

Bioactivity	Fluorofolin is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.5 nM. Fluorofolin exhibits significant activity against P. aeruginosa[1].
Invitro	Fluorofolin 对铜绿假单胞菌 PA14 表现出强效活性（MIC 为 3.1 µg/ml）。Fluorofolin 具有广谱抗生素活性，因为它还能够抑制另外两种铜绿假单胞菌菌株 PA01 和 ATTC 27853[1] 的生长。在补充胸腺嘧啶的情况下，Fluorofolin 活性对铜绿假单胞菌[1] 具有选择性。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Fluorofolin 相关抗体:
In Vivo	在小鼠中，Fluorofolin 表现出良好的血浆蛋白结合率（结合率为 71.7%，恢复率为 91.9%）。口服后，Fluorofolin 的峰浓度达到 4.0 μg/mL，半衰期为 12.1 h[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2757070-32-7
Formula	C16H13FN6
Molar Mass	308.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Connor Chain, et al. A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting. Nat Microbiol. 2024 May;9(5):1207-1219.

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