Flonoltinib sulfate_product_DataBase

Bioactivity	Flonoltinib maleate is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. Flonoltinib maleate has anti-cancer activity[1].
Invitro	Flonoltinib maleate (0.008-1 μM; for 2 hours) down-regulates p-FLT3 in a dose-dependent manner[1].Flonoltinib maleate (5-100 nM; for 2 hours) has a dose-dependent effect on the induction of apoptosis in the MV4-11 cells[1].Flonoltinib maleate (5-100 nM; for 2 hours) strongly induces cell cycle arrest with a G1/G0 percentage of 85% at 100 nM in the MV4-11 cells[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Flonoltinib sulfate 相关抗体:
In Vivo	Flonoltinib maleate (30 and 60 mg/kg/day; p.o.; for 14 days) exhibits significant antitumor effects[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2568842-57-7
Formula	C25H36FN7O5S
Molar Mass	565.66
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yang T, et al. Discovery of Potent and Orally Effective Dual JAK2/FLT3 Inhibitors for the Treatment of AcuteMyelogenous Leukemia and Myeloproliferative Neoplasms. J Med Chem. 2019 Oct 31.

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