| Bioactivity | Flonoltinib maleate is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 has anti-cancer activity[1]. |
| Invitro | Flonoltinib maleate (0.008-1 μM; for 2 hours) 以剂量依赖的方式下调 p-FLT3[1]。Flonoltinib maleate (5-100 nM; for 2 hours) 对诱导 MV4-11 细胞凋亡有剂量依赖性[1]。lonoltinib maleate (5-100 nM; for 2 hours) 在 MV4-11 细胞中，100 nM 时 G1/G0 百分比为 85%，强烈诱导细胞周期阻滞[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Flonoltinib maleate 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | Flonoltinib maleate (30 and 60 mg/kg/day; 口服.; 持续14 天) 具有显著的抗肿瘤作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C29H38FN7O5 |
| Molar Mass | 583.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang T, et al. Discovery of Potent and Orally Effective Dual JAK2/FLT3 Inhibitors for the Treatment of AcuteMyelogenous Leukemia and Myeloproliferative Neoplasms. J Med Chem. 2019 Oct 31. |