Fipronil_product_DataBase

Bioactivity	Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC50s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes[1][2].
Invitro	氟虫腈 (0.1-25 µM; 72 h) 剂量依赖性地诱导人类肝细胞中 CYP1A1 和 CYP3A4 mRNA 的表达[1]。氟虫腈 (0.1-25 µM; 72 h) 以时间和剂量依赖的方式诱导 HepG2 细胞中的 caspase-3/7 (caspase-3/7活性是细胞凋亡过程的重要标志物)[1]。 RT-PCR[1] Cell Line:
Name	Fipronil
CAS	120068-37-3
Formula	C12H4Cl2F6N4OS
Molar Mass	437.15
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

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