| Bioactivity | Fibrostatin C is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery[1]. |
| CAS | 91776-47-5 |
| Formula | C18H19NO8S |
| Molar Mass | 409.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ishimaru T, et al. Inhibition of prolyl hydroxylase activity and collagen biosynthesis by fibrostatin C, a novel inhibitor produced by Streptomyces catenulae subsp. griseospora No. 23924. J Antibiot (Tokyo). 1988 Nov;41(11):1668-74. [2]. Saika S, et al. Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro. Graefes Arch Clin Exp Ophthalmol. 1996 Aug;234 Suppl 1:S214-22. |
Fibrostatin C
CAS: 91776-47-5 F: C18H19NO8S W: 409.41
Fibrostatin C is an orally active prolyl hydroxylase inhibitor that also inhibits collagen biosynthesis. Fibrostatin C a
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