FiVe1

CAS: 932359-76-7 F: C18H16Cl2N4 W: 359.25

FiVe1 is a potent vimentin (VIM; the intermediate filament and mesenchymal marker)inhibitor. FiVe1 promotes VIM disorgan

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Bioactivity	FiVe1 is a potent vimentin (VIM; the intermediate filament and mesenchymal marker) inhibitor[1]. FiVe1 promotes VIM disorganization and phosphorylation during metaphase, leading to mitotic catastrophe, multinucleation, and the loss of stemness.?FiVe1 selectively and irreversibly inhibits the growth of multiple FOXC2-expressing breast cancer cell lines (HMLER cells (IC50:?267 nM); FOXC2-HMLER cells (IC50:?447 nM). FiVe1 inhibits the migration of mesenchymally transformed cells[1].
Target	IC50: VIM
Name	FiVe1
CAS	932359-76-7
Formula	C18H16Cl2N4
Molar Mass	359.25
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Michael J Bollong, et al. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912.