Ferrous bisglycinate_product_DataBase

Bioactivity	Ferrous bisglycinate is an orally active iron fortificants and therapeutic iron supplements. Ferrous bisglycinate can be used for the research of iron deficiency anemia[1][2].
Invitro	Ferrous bisglycinate (25-200 μM; 2 h) does not affect the Caco-2 cells viability[2].Ferrous bisglycinate (25 μM; 2 h) increases ferritin content in the Caco-2 cells[2]. Cell Viability Assay[2] Cell Line:
In Vivo	Ferrous bisglycinate (500 mg/kg iron; p.o.) exerts a protective effect on colitis in mice[3]. Animal Model:
Name	Ferrous bisglycinate
CAS	20150-34-9
Formula	C4H6FeN2O4
Molar Mass	201.95
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Reference	[1]. Ferrari P, et, al. Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate. Biomed Pharmacother. 2012 Sep; 66(6): 414-8. [2]. Yu X, et, al. Iron Transport from Ferrous Bisglycinate and Ferrous Sulfate in DMT1-Knockout Human Intestinal Caco-2 Cells. Nutrients. 2019 Feb 26; 11(3): 485. [3]. Constante M, et, al. Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis. Inflamm Bowel Dis. 2017 May; 23(5): 753-766.

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