| Bioactivity | Ferroptosis-IN-8 is a potent ferroptosis inhibitor with an EC50 of 40.49 nM. Ferroptosis-IN-8 effectively reduces lipid ROS levels in cells. Ferroptosis-IN-8 act as an antioxidant by capturing lipid radicals, leading to a reduction in the accumulation of harmful lipid peroxides and, ultimately, inhibiting ferroptosis[1]. |
| Invitro | Ferroptosis-IN-8（化合物 B4）可有效拯救 HKC、HT-1080、HK-2、Khos、SW480 和 HTR-8/SVneo 细胞免于由 RSL3 或 FIN56 诱导的铁死亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Ferroptosis-IN-8 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | Ferroptosis-IN-8（化合物 B4；10 mg/kg）通过抑制铁死亡，显著减轻肾脏缺血再灌注损伤和对乙酰氨基酚诱导的急性肝损伤中的组织损伤[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C15H15N3O3 |
| Molar Mass | 285.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xie-Huang Sheng, et al. Discovery of Novel Ortho-Aminophenol Derivatives Targeting Lipid Peroxidation with Potent Antiferroptotic Activities. J Med Chem. 2024 Jun 1. |