| Bioactivity | Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1][2][3]. |
| Invitro | Fenspiride (around 100 μM) inhibits histamine-induced contraction of isolated guinea pig trachea[2].Fenspiride (≤1000 μM) produces less than 25% inhibition of phosphodiesterase 1 and phosphodiesterase 2 activities[2]. |
| Name | Fenspiride hydrochloride |
| CAS | 5053-08-7 |
| Formula | C15H21ClN2O2 |
| Molar Mass | 296.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Fenspiride hydrochloride
CAS: 5053-08-7 F: C15H21ClN2O2 W: 296.79
Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride
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