| Bioactivity | Fargesone A is a potent and selective FXR agonist. Fargesone A shows anti-inflammatory activity[1]. |
| Target | FXR |
| Invitro | Fargesone A (10 μM; 24 h) 以 FXR 依赖的方式减轻人肝脏 WRL68 细胞的肝细胞紊乱[1]。Fargesone A 的激动作用是通过与 FXR 的直接相互作用实现的[1]。 |
| In Vivo | Fargesone A (3 and 30 mg/kg; i.p.; daily for 7 days) 可显著改善胆管结扎 (BDL) 诱导的慢性肝纤维化小鼠模型[1]。Pharmacokinetics parameters of Fargesone A in mice |
| Name | Fargesone A |
| CAS | 116424-69-2 |
| Formula | C21H24O6 |
| Molar Mass | 372.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guo F, et al. Biomimetic Total Synthesis and the Biological Evaluation of Natural Product (-)-Fargesone A as a Novel FXR Agonist. JACS Au. 2022 Dec 7;2(12):2830-2838. |