| Bioactivity | FZD7 antagonist 1 (peptide 34) is a dFz7-21 analogue. FZD7 antagonist 1 is an FZD7 antagonist that inhibits the wnt3a with IC50 value of 9.2 nM. FZD7 antagonist 1 blocks TcdB−FZD interaction via targeting FZD receptors[1]. |
| Name | FZD7 antagonist 1 |
| CAS | 2416664-25-8 |
| Sequence | Chain 1: Ac-Thr-Asp-Asp-Leu-Glu-Leu-Trp-Cys-His-Ile-Met-Tyr-NH2; Chain 2: Ac-Thr-Asp-Asp-Leu-Glu-Leu-Trp-Cys-His-Ile-Met-Tyr-NH2 (Disulfide bridge: Chain 1: Cys8-Chain 2: Cys8) |
| Shortening | Chain 1: Ac-TDDLELWCHIMY-NH2; Chain 2: Ac-TDDLELWCHIMY-NH2 (Disulfide bridge: Chain 1: Cys8-Chain 2: Cys8) |
| Formula | C142H202N32O42S4 |
| Molar Mass | 3157.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Simon Hansen, et al. Lead Optimization Yields High Affinity Frizzled 7-Targeting Peptides That Modulate Clostridium difficile Toxin B Pathogenicity in Epithelial Cells. J Med Chem. 2019, 62, 17. [2]. Fei Wang, et al. Alstonic acids A and B, unusual 2,3-secofernane triterpenoids from Alstonia scholaris. Phytochemistry. 2009, 70, 5. |
FZD7 antagonist 1
CAS: 2416664-25-8 F: C142H202N32O42S4 W: 3157.57
FZD7 antagonist 1 (peptide 34) is a dFz7-21 analogue. FZD7 antagonist 1 is an FZD7 antagonist that inhibits the wnt3a wi
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