FXIIIa-IN-1_product_DataBase

Bioactivity	FXIIIa-IN-1 (Compound 16) is a potent and selective FXIIIa (Factor XIIIa) inhibitor with an IC50 value of 2.4 μM. FXIIIa-IN-1 inhibits FXIIIa by competing with the Gln-donor protein substrate (dimethylcasein). FXIIIa-IN-1 holds promise for the development of effective and safe novel anticoagulants[1].
Target	IC50: 2.4 μM (Factor XIIIa); IC50: > 150 μM (Factor XIa); IC50: > 500 μM (Factor Xa); IC50: > 500 μM (Thrombin);
Invitro	FXIIIa-IN-1 (10 μM，3 天) 在乳腺 (MCF-7 细胞)、肠道 (CaCo-2 细胞) 和肾脏 (HEK-293 细胞) 三种细胞系中无显著细胞毒性[1]。FXIIIa-IN-1 (5-2000 μM，24 小时) 浓度依赖性地抑制基于 FXIIIa 的纤维蛋白 (ogen) 聚合和 γ-γ 二聚体的形成[1]。FXIIIa-IN-1 (5 μL，5 min) 未影响其他凝血因子 (thrombin, factor Xa, factor XIa) ，对 FXIIIa 具有选择性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> FXIIIa-IN-1 相关抗体: Cell Cytotoxicity Assay[1] Cell Line:
CAS	55909-92-7
Formula	C26H25N5O19S6
Molar Mass	903.89
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Vu KT, et al. Discovery of Heparin Mimetic, Potent, and Selective Inhibitors of Human Clotting Factor XIIIa. ACS Omega. 2024 Jul 3;9(28):31105-31119.

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