| Bioactivity | FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) specific inhibitor, with a Ki of 8 μM. FX-11 can effectively activate PKM2 (pyruvate kinase M2). FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts[1][2]. | |||||||||
| Invitro | FX-11 (9 μM, 24-48 h) shows activation of AMP kinase and phosphorylation of its substrate acetyl-CoA carboxylase[2].FX-11 (0-100 µM, 72 h) inhibits cell proliferation in BxPc-3 and MIA PaCa-2 cells[3].FX-11 inhibits glycolysis and alters cellular energy metabolism in P493 cells[2]. Western Blot Analysis[2] Cell Line: | |||||||||
| Name | FX-11 | |||||||||
| CAS | 213971-34-7 | |||||||||
| Formula | C22H22O4 | |||||||||
| Molar Mass | 350.41 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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