| Bioactivity | FUT8-IN-1 (Compound 37) is an inhibitor for α-1,6-fucosyltransferase (FUT8) with an KD of 49 nM and an IC50 of ca. 50 µM. FUT8-IN-1 generates a highly active naphthoquinone imine intermediate in the presence of FUT8, and inhibits the enzymatic activity of FUT8[1]. |
| Formula | C23H25ClN2O |
| Molar Mass | 380.91 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Manabe Y, et al. Development of a FUT8 Inhibitor with Cellular Inhibitory Properties[J]. Angewandte Chemie International Edition, 2024, 63(52): e202414682. |