| Bioactivity | FSK hydrochloride is fluorosulfonyloxybenzoyl-l-lysine, with a long and flexible aryl fluorosulfate-containing side chain that can reach protein sites that are difficult to reach by covalent linkage. FSK hydrochloride is a modified nanomolecule that targets the epidermal growth factor receptor (EGFR), creating a covalent binding that results in irreversible binding. FSK hydrochloride captures unknown enzyme-substrate interactions in living cells through genetically encoded chemical cross-linking, targeting residues beyond Cys, and cross-linking at the binding periphery. FSK hydrochloride enables the construction of bioreactive SuFEx systems for creating covalent bonds in different proteins in vitro and in vivo[1]. |
| CAS | 3033987-42-4 |
| Formula | C13H18ClFN2O6S |
| Molar Mass | 384.81 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu J, et al. A Genetically Encoded Fluorosulfonyloxybenzoyl-l-lysine for Expansive Covalent Bonding of Proteins via SuFEx Chemistry. J Am Chem Soc. 2021 Jul 14;143(27):10341-10351. |
FSK hydrochloride
CAS: 3033987-42-4 F: C13H18ClFN2O6S W: 384.81
FSK hydrochloride is fluorosulfonyloxybenzoyl-l-lysine, with a long and flexible aryl fluorosulfate-containing side chai
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