| Bioactivity | FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR[1]. |
| Target | pEC50: 7.72 (FSHR) |
| Invitro | FSHR agonist 1 (compound 21f) 与 FSHR TMD 口袋的结合诱导 TM6 和 TM7 向内运动，这直接导致 FSHR 激活[1]。FSHR agonist 1 (compound 21f) 可以高效激活 FSHR、LHCGR 和 TSHR，而对 FSHR 的激活效力比 LHCGR（pEC50 为 6.26）和 TSHR（pEC50 为 6.48）高 10 倍以上[1]。 |
| Name | FSHR agonist 1 |
| CAS | 1256776-89-2 |
| Formula | C26H33N3O3S |
| Molar Mass | 467.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jia Duan, et al. Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follicle stimulating hormone receptor. biorxiv. August 01, 2022. |
FSHR agonist 1
CAS: 1256776-89-2 F: C26H33N3O3S W: 467.62
FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.
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