| Bioactivity | FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. FSEN1 triggers iron death in cancer cells by inhibiting FSP1. FSEN1 can be used in research of cancer[1]. |
| Invitro | FSEN1 (0-15 µM; H460C Cas9 细胞) 对 GPX4 抑制剂具有合成致死作用，并通过抑制 FSP1 使癌细胞对铁死亡敏感[1]。 |
| Name | FSEN1 |
| CAS | 862808-01-3 |
| Formula | C22H22BrN5OS |
| Molar Mass | 484.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hendricks JM, et, al. Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem Biol. 2023 May 4:S2451-9456(23)00114-9. |