| Bioactivity | FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects[1]. |
| Target | PICK1. |
| Invitro | FSC231 (50 μM) 阻断 COS7 细胞中 GluR2 与 PICK1 之间的结合[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> FSC231 相关抗体: |
| In Vivo | FSC231 (总共 78.40 μg/kg，每日，腹腔注射七次，紫杉醇给药前 3 小时) 可减轻紫杉醇 (HY-B0015) 诱导的大鼠神经痛[1]。FSC231 (39.2 μg/kg/天，腹腔注射，持续 4 周) 部分通过 PICK1/eNOS/cGMP 通路抑制 ROS 生成和细胞凋亡，从而抑制大鼠糖尿病心肌病的发展[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 1215849-96-9 |
| Formula | C13H10Cl2N2O3 |
| Molar Mass | 313.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang X, et al. FSC231 alleviates paclitaxel-induced neuralgia by inhibiting the interactions between PICK1 and GluA2 and activates GSK-3β and ERK1/2. Brain Behav. 2021 Nov;11(11):e2380. [2]. Thorsen TS, et al. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):413-8. [3]. Cai Fei, et al. GW27-e1146 PICK1 inhibition restores myocardial injury by suppressing reactive oxygen species generation and apoptosis in diabetic rats. J Am Coll Cardiol. 2016 Oct, 68 (16_Supplement) C67. |