| Bioactivity | FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1]. | |||||||||
| Invitro | FR901464 (10-20 ng/ml; 6-24 hours) inhibits the growth of murine solid tumors, Colon 38 carcinoma and Meth A fibrosarcoma. FR901464 induces characteristic G1 and G2/M phase arrest in the cell cycle and internucleosomal degradation of genomic DNA with the same kinetics as activation of SV40 promoter-dependent cellular transcription in M-8 tumor cells[1].FR901464 (1-10 ng/ml; 16 hours) suppresses the transcription of some inducible endogenous genes but not house keeping genes in M-8 cells[1].FR901464 exhibits potent anticancer activity. It shows enhancement of activity of a promoter of the SV40 DNA tumor virus at 10 nM concentration in M-8 cells[1]. | |||||||||
| Name | FR901464 | |||||||||
| CAS | 146478-72-0 | |||||||||
| Formula | C27H41NO8 | |||||||||
| Molar Mass | 507.62 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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