FR173657

CAS: 167838-64-4 F: C30H27Cl2N5O4 W: 592.47

FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor

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Bioactivity	FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease[1].
Target	0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively
Name	FR173657
CAS	167838-64-4
Formula	C30H27Cl2N5O4
Molar Mass	592.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Asano M, et al. The identification of an orally active, nonpeptide bradykinin B2 receptor antagonist, FR173657. Br J Pharmacol. 1997 Feb;120(4):617-24.