FOY 251 free base_product_DataBase

Bioactivity	FOY 251 free base, an anti-proteolytic active metabolite of Camostate (HY-13512), acts as a proteinase inhibitor[1][2]. FOY 25 free base inhibits SARS-CoV-2 infection in cells assay[3].
Target	Proteinase
Invitro	FOY 251 free base represents a dose-dependent inhibition of equivalent current in M-1 cells[2].FOY-251 free base inhibits the proteolytic activity of prostasin[2].
Name	FOY 251 free base
CAS	71079-08-8
Formula	C16H15N3O4
Molar Mass	313.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. K Beckh, et al. Elimination of the Low-Molecular Weight Proteinase Inhibitor Camostate (FOY 305) and Its Degradation Products by the Rat Liver. Res Exp Med (Berl). 1987;187(6):401-6. [2]. Ai Maekawa, et al. Camostat Mesilate Inhibits Prostasin Activity and Reduces Blood Pressure and Renal Injury in Salt-Sensitive Hypertension. J Hypertens . 2009 Jan;27(1):181-9. [3]. Markus Hoffmann, et al. Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. bioRxiv. 2020 Aug 5;2020.08.05.237651.

PeptideDB