| Bioactivity | FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells[1]. |
| Invitro | FOXO4-DRI (25 mM; 3 days) 引起活性 p53 的核排斥，诱导衰老 TM3 Leydig 细胞凋亡[1]。FOXO4-DRI (25 μM; 5 days) 显著降低 PDL9 细胞的衰老水平[2]。 Cell Viability Assay[1] Cell Line: |
| Name | FOXO4-DRI |
| CAS | 2460055-10-9 |
| Sequence | D-(Leu-Thr-Leu-Arg-Lys-Glu-Pro-Ala-Ser-Glu-Ile-Ala-Gln-Ser-Ile-Leu-Glu-Ala-Tyr-Ser-Gln-Asn-Gly-Trp-Ala-Asn-Arg-Arg-Ser-Gly-Gly-Lys-Arg-Pro-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly) |
| Shortening | D-(LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRPPPRRRQRRKKRG) |
| Formula | C228H388N86O64 |
| Molar Mass | 5358.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
FOXO4-DRI
CAS: 2460055-10-9 F: C228H388N86O64 W: 5358.06
FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic
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