| Bioactivity | FLS-359 is a selective, orally active allosteric modulator for sirtuin 2, with the IC50 of 3 μM. FLS-359 exhibits antiviral activity against RNA and DNA virus, through inhibition of DNA/RNA replication[1]. |
| Invitro | FLS-359 (0-100 μM) 抑制 SIRT2 在组蛋白 H3 位点上的脱乙酰化，并具有底物选择性[1]。FLS-359 抑制多种 RNA 和 DNA 病毒的生长，如 SARS-CoV-2、甲型流感、乙型肝炎、呼吸道合胞病毒，IC50 范围为 0.3- 6.7 μM[1]。FLS-359 (0-10 μM，24 h) 抑制 Akata 细胞中 Epstein-Barr 病毒 (EBV) 的裂解激活，以及二倍体成纤维细胞中人巨细胞病毒 (HCMV) 的传播 (IC50 0.466 μM)[1]。FLS-359 (0-5 μM，72 h) 抑制细胞内病毒核酸的积累、细胞外病毒颗粒的产生以及病毒颗粒的感染性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> FLS-359 相关抗体: |
| In Vivo | FLS-359 (50 mg/kg，口服，单剂量) 表现出良好的血浆暴露度，血浆半衰期为 6 小时，最大血浆浓度 Cmax 为 89 μM，AUC 为 713 μM•h/mL[1]。FLS-359 (50 mg/kg，口服，一天两次，共 11 天) 可抑制免疫缺陷小鼠感染人巨细胞病毒 (HCMV)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2309398-79-4 |
| Formula | C27H26N6S |
| Molar Mass | 466.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Roche KL, et al., An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity. J Clin Invest. 2023 Jun 15;133(12):e158978. |