| Bioactivity | FH1 (NSC 12407) enhances hepatocyte functions, and promotes the differentiation of induced pluripotent stem (iPS)-derived hepatocytes toward a phenotype more mature and the maturation of well-differentiated cultures of hepatocyte-like cells (iHeps)[1]. | ||||||||||||
| Invitro | FH1 (NSC 12407, 5 µg/mL, 0-40 days) enhances hepatic maturation and maintain the hepatic differentiation state of hiPSC-HLCs[2]. RT-PCR[2] Cell Line: | ||||||||||||
| Name | FH1 | ||||||||||||
| CAS | 2719-05-3 | ||||||||||||
| Formula | C17H18N2O2 | ||||||||||||
| Molar Mass | 282.34 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug;9(8):514-20. [2]. Lunzhi Yuan, et al. A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection. Front Microbiol. 2018 May 8;9:908. |