FGFR-IN-11_product_DataBase

Bioactivity	FGFR-IN-11 (compound I-5) is an orally active and covalent FGFR inhibitor with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4), respectively. FGFR-IN-11 inhibits multiple cancer cell proliferation with nanomolar activity. FGFR-IN-11 inhibits tumor growth significantly in xenograft mice models[1].
Invitro	FGFR-IN-11 (0.3 nM-20 μM， 72 h) 以纳摩尔活性抑制多种癌细胞生长[1]。 Cell Viability Assay[1] Cell Line:
In Vivo	FGFR-IN-11 (60 mg/kg，口服，每天一次， 21 天) 在雌性裸鼠的 Huh-7 或 NCI-H1581 异种移植瘤模型中显著抑制肿瘤生长并且不影响小鼠体重。[1] Animal Model:
Name	FGFR-IN-11
CAS	2658488-68-5
Formula	C28H29ClN4O4
Molar Mass	521.01
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hu S, et al. Discovery and Structural Optimization of Novel Quinolone Derivatives as Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors. J Med Chem. 2023 Jul 13;66(13):8858-8875.

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