| Bioactivity | FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices[1][2]. |
| Invitro | FFN511 (350 nM; 30 min) accumulats in a pattern consistent with LDCVs in cultured mouse chromaffin cells, and the accumulation is abolished by the lipophilic base chloroquine[1]. Cell Viability Assay[1] Cell Line: |
| Name | FFN511 |
| CAS | 1004548-96-2 |
| Formula | C17H20N2O2 |
| Molar Mass | 284.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gubernator NG, et al. Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science. 2009 Jun 12;324(5933):1441-4. [2]. Keighron JD, et al. Analytical tools to monitor exocytosis: a focus on new fluorescent probes and methods. Analyst. 2012 Apr 21;137(8):1755-63. |