| Bioactivity | FFN246 is a fluorescent, dual substrate of serotonin transporter (SERT) probe and vesicular monoamine transporter 2 (VMAT2) with excitation and emission spectra 392/427 nm. FFN246 can be used for labeling serotonergic neurons in mouse brain tissue through SERT-dependent accumulation[1]. |
| In Vivo | FFN246 (2.5-20 μM, 30 mins) 可用于 96 孔板细胞培养实验中 5-羟色胺转运体(serotonin transporter, SERT) 活性和SERT 抑制剂的直接检测，也可用于急性小鼠脑片活体组织中缝背核 5-羟色胺能神经元的特异性标记[1]。FFN246 (20 μM, 30 min) 可有效追踪 5-羟色胺能神经元体细胞中 5-羟色胺的摄取和包装[1]。 |
| Name | FFN246 |
| CAS | 2210244-83-8 |
| Formula | C15H13FN2O |
| Molar Mass | 256.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Henke A, et al. Toward Serotonin Fluorescent False Neurotransmitters: Development of Fluorescent Dual Serotonin and Vesicular Monoamine Transporter Substrates for Visualizing Serotonin Neurons. ACS Chem Neurosci. 2018;9(5):925-934. |