| Bioactivity | FFA3 agonist 1 is an agonist of free fatty acid receptor 3 (FFA3). FFA3 agonist 1 regulates the health effect of intestinal microbiota by activating FFA3[1]. |
| Invitro | FFA3 agonist 1 (0.01-100 µM) 增加诱导表达增强黄色荧光蛋白 (eYFP) 人游离脂肪酸受体 3 (hFFA3) 的 Flp-in-T-REx 293 细胞中的 [35S]GTPgS 的掺入和 pERK1/2 的产生，减少中 cAMP 的产生[2]。FFA3 agonist 1 (0.1-100 µM) 增加人游离脂肪酸受体 3、鼠游离脂肪酸受体 3 (mFFA3)、兔游离脂肪酸受体 3 (rFFA3) 中 [35S]GTPgS 的掺入[2]。 |
| Name | FFA3 agonist 1 |
| CAS | 886358-51-6 |
| Formula | C22H22N2O3 |
| Molar Mass | 362.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ulven ER, et al. Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators. J Med Chem. 2020 Apr 9;63(7):3577-3595. [2]. Hudson BD, Christiansen E, Murdoch H, Jenkins L, Hansen AH, Madsen O, Ulven T, Milligan G. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 2014 Aug;86(2):200-10. |
FFA3 agonist 1
CAS: 886358-51-6 F: C22H22N2O3 W: 362.42
FFA3 agonist 1 is an agonist of free fatty acid receptor 3 (FFA3). FFA3 agonist 1 regulates the health effect of intesti
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