| Bioactivity | FERb 033 is a selective and potent ERβ agonist (Ki=7.1 nM, EC50=4.8 nM). FERb 033 shows 62-fold selectivity over ERα[1]. |
| Invitro | FERb 033 (0-100 μM) shows specificity on full-length of estrogen receptor (ESR) in transactivation[2].FERb 033 (10 nM, 2 h) treatment mildly decreases Ca2+ response in airway smooth muscle (ASM) cells[3]. Cell Viability Assay[2] Cell Line: |
| Name | FERb 033 |
| CAS | 1111084-78-6 |
| Formula | C13H9ClFNO3 |
| Molar Mass | 281.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Filippo Minutolo, et al. Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta. J Med Chem. 2009 Feb 12;52(3):858-67. [2]. Satomi Kohno, et al. Estrogen receptor 1 (ESR1; ERα), not ESR2 (ERβ), modulates estrogen-induced sex reversal in the American alligator, a species with temperature-dependent sex determination. Endocrinology. 2015 May;156(5):1887-99. [3]. Sangeeta Bhallamudi, et al. Estrogen receptors differentially regulate intracellular calcium handling in human nonasthmatic and asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L112-L124. |