| Bioactivity | FAUC 346, a highly selective D3 partial agonist (EC50 = 1.5 nM), also demonstrates an inhibitory effect on cocaine-seeking behavior[1][2]. |
| Invitro | FAUC 346, an in vitro D3-selective ligand with a Ki of 0.23 nM in CHO cells for D3 receptor[1].FAUC346 shows some affinity for 5HT1A receptors (Ki = 41 nM) and for α1 receptors (Ki = 15 nM)[1]. |
| Name | FAUC 346 |
| CAS | 474432-65-0 |
| Formula | C24H29N3O2S |
| Molar Mass | 423.57 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Bertrand Kuhnast, et al. Synthesis and radiolabeling of N-[4-[4-(2-[11C]methoxyphenyl)piperazin-1-yl]butyl]benzo[b]thiophene-2-carboxamide -- a potential radiotracer for D3 receptor imaging with PET. Nucl Med Biol. 2006 Aug;33(6):785-95. [2]. Carsten Hocke, et al. 18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor. ChemMedChem. 2008 May;3(5):788-93. |
FAUC 346
CAS: 474432-65-0 F: C24H29N3O2S W: 423.57
FAUC 346, a highly selective D3 partial agonist (EC50 = 1.5 nM), also demonstrates an inhibitory effect on cocaine-seeki
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