| Bioactivity | FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29)[1]. FASN-IN-4 also inhibits SARS-CoV-2 with an EC50 of 18.6 nM[2]. | ||||||||||||
| Target | IC50: 10 nM (FASN)EC50: 18.6 nM (SARS-CoV-2) | ||||||||||||
| Invitro | The FASN inhibitor, FASN-IN-4 inhibits SARS-CoV-2 replication, and has the potential for COVID-19 research[2]. | ||||||||||||
| Name | FASN-IN-4 | ||||||||||||
| CAS | 1375105-96-6 | ||||||||||||
| Formula | C26H27N3O4S | ||||||||||||
| Molar Mass | 477.58 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1. [2]. Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3(11):1466-1475. |
FASN-IN-4
CAS: 1375105-96-6 F: C26H27N3O4S W: 477.58
FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29). FASN-
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