| Bioactivity | FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2, a 5-FAM labeled HIF-1α peptide, is a substrate of VHL. FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2 binds to VHL protein with a KD of 3 nM. Ex/Em (λ) = 485/520 nm[1]. |
| Name | FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2 |
| Sequence | {FAM}-Asp-Glu-Ala-Leu-Ala-{Hyp}-Tyr-Ile-Pro-Met-Asp-Asp-Asp-Phe-Gln-Leu-Arg-Ser-Phe-NH2 |
| Shortening | {FAM}-DEALA-{Hyp}-YIPMDDDFQLRSF-NH2 |
| Formula | C122H158N24O39S |
| Molar Mass | 2616.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dennis L Buckley, et al. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction. J Am Chem Soc. 2012 Mar 14;134(10):4465-8. |
FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2
CAS: F: C122H158N24O39S W: 2616.76
FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2, a 5-FAM labeled HIF-1α peptide, is a substrate of VHL. FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2
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