| Bioactivity | FABP5-IN-1 is a selective and high affinity fatty acid binding protein 5 (FABP5) inhibitor with a Ki value of 1.7 μM, and does not bind to both FABP3 and FABP7. FABP5-IN-1 shows potent antinociceptive effects[1]. | |||||||||
| Target | Ki: 1.7 μM (FABP5) | |||||||||
| In Vivo | FABP5-IN-1 (Compounds 4j; 20 mg/kg; intraperitoneal injection; for 90 minutes; male wild-type C57BL/6 mice) treatment displays potent antinociceptive effects in CFA model[1]. Animal Model: | |||||||||
| Name | FABP5-IN-1 | |||||||||
| CAS | 2132990-98-6 | |||||||||
| Formula | C34H30O6 | |||||||||
| Molar Mass | 534.60 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Yan S, et al. SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins. Eur J Med Chem. 2018 Jun 25;154:233-252. |