| Bioactivity | FABP4-IN-3 (compound C3) is a highly selective FABP4 inhibitor (FABP4 Ki = 25 ± 3a nM, FABP3 Ki = 15.03 μM) which exhibits a 601-fold selectivity over FABP3. FABP4-IN-3 also shows metabolic stability and potent cellular anti-inflammatory activity, making it promising to get involved in the research of metabolic disease, cardiac dysfunction and inflammation-related disease[1]. |
| Invitro | FABP4-IN-3 在人和小鼠微粒体中均表现出显著的代谢稳定性， T1/2 分别为 165 min 和 131 min[1]。FABP4-IN-3 (100μM, 24h) 对 THP-1 巨噬细胞的细胞活力无细胞毒性作用[1]。FABP4-IN-3 (5-20μM, 18h) 表现出明显的、剂量依赖性的对抑制炎症细胞因子 MCP-1 产生的抑制[1]。 0 --> FABP4-IN-3 相关抗体: |
| Name | FABP4-IN-3 |
| Formula | C20H16ClNO2 |
| Molar Mass | 337.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yechun Xu, et al. Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3. European Journal of Medicinal Chemistry. 2023，Journal Pre-proof. |