| Bioactivity | FAAH-IN-7 is a reversible and potent FAAH inhibitor with an IC50 value of 8.29 nM. FAAH-IN-7 suppresses oxidative stress in 1321N1 astrocytes and exhibits notable neuroprotective effect in ex vivo neuroinflammation model[1]. |
| Invitro | FAAH-IN-7 (化合物 4e) (10 nM-30 μM; 24 h) 小鼠成纤维细胞NIH3T3和人星形胶质细胞1321N1无细胞毒性，且对Ki值为>10 μM的[1]。FAAH-IN-7 (10 nM, 100 nM; 30 min) 通过可逆机制抑制 FAAH。快速稀释破坏了抑制剂和酶之间的平衡，导致酶活性恢复[1]。FAAH-IN-7 (1 nM-1 μM; 24 h) 在 1321N1 星形胶质细胞中，从 10 nM 开始显著减少活性氧 (ROS) 的产生[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | FAAH-IN-7 (化合物 4e) 在大鼠海马外植体炎症诱导的神经退变体外培养中显示抗炎作用[1]。 |
| Name | FAAH-IN-7 |
| Formula | C26H29N3O4 |
| Molar Mass | 447.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Papa A, et al. Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions. Eur J Med Chem. 2022 Nov 25;246:114952. |