| Bioactivity | Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs). | ||||||||||||
| Name | Exatecan Intermediate 5 | ||||||||||||
| CAS | 143655-70-3 | ||||||||||||
| Formula | C15H17FN2O3 | ||||||||||||
| Molar Mass | 292.31 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10. [2]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. |
Exatecan Intermediate 5
CAS: 143655-70-3 F: C15H17FN2O3 W: 292.31
Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhib
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