| Bioactivity | Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells[1]. |
| Invitro | Euptox A (0-2 μg/mL, 48 h) 有效抑制HeLa细胞增殖[1]。Euptox A（0-50 μg/mL，24 小时）阻止细胞周期从 S 期到 G2/M 期的转变[1]。Euptox A 在体外以剂量依赖的方式对人肺癌 A549、HeLa 和 Hep-2 细胞系表现出显着的抗肿瘤活性[1]。Euptox A 在体外对 S.scabiei 和P. cuniculi 表现出高度杀螨活性[1]。 |
| Name | Euptox A |
| CAS | 79491-71-7 |
| Formula | C15H20O2 |
| Molar Mass | 232.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liao F, et al. Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum. Oncol Rep. 2015 Apr;33(4):1823-7. |