| Bioactivity | Eugenol acetate-d3 is deuterated labeled Decyl aldehyde (HY-W012570). Decyl aldehyde is a simple ten-carbon aldehyde. Decyl aldehyde is a bacterial luciferase substrate. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Eugenol acetate-d3 相关抗体: |
| In Vivo | Eugenol acetate (15% v/v, 共 30 μL; 每周 2 次, 共 28 周) 引起小鼠皮肤的 p53 和 p21WAF1 表达增加，和癌组织中细胞凋亡[3]。Eugenol acetate (3-300 mg/kg; 口服或腹腔注射, 单剂量) 可发挥镇痛作用，抑制乙酸、谷氨酸盐、红藻氨酸引起的不同的小鼠急性疼痛模型[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C12H11D3O3 |
| Molar Mass | 209.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Kaur G, et al. Eugenol precludes cutaneous chemical carcinogenesis in mouse by preventing oxidative stress and inflammation and by inducing apoptosis. Mol Carcinog. 2010 Mar;49(3):290-301. [3]. Dal Bó W, et al. Eugenol reduces acute pain in mice by modulating the glutamatergic and tumor necrosis factor alpha (TNF-α) pathways. Fundam Clin Pharmacol. 2013 Oct;27(5):517-25 [4]. Musthafa KS, et al. Antifungal potential of eugenyl acetate against clinical isolates of Candida species. Microb Pathog. 2016 Oct;99:19-29. |