Eudebeiolide B_product_DataBase

Bioactivity	Eudebeiolide B is a compound isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating RANKL-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research[1].
Invitro	Eudebeiolide B (1-30 μΜ，1 小时) 在小鼠骨髓巨噬细胞中抑制 RANKL 诱导的细胞分化，抑制破骨细胞生成相关标志基因的表达和 RANKL 介导的细胞信号传导[1]。 Cell Differentiation Assay[1] Cell Line:
In Vivo	Eudebeiolide B (5 或 10 mg/kg 灌胃.，每天 1 次，持续 6 周) 在卵巢切除（OVX）小鼠模型中，可预防双侧卵巢切除 (OVX) 引起的骨质流失[1]。 Animal Model:
Name	Eudebeiolide B
CAS	1934299-51-0
Formula	C15H18O4
Molar Mass	262.30
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kim MH,et.al. Eudebeiolide B Inhibits Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Regulating RANKL-Induced NF-κB, c-Fos and Calcium Signaling. Pharmaceuticals (Basel). 2020 Dec 16;13(12):468.

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